abstract：OBJECTIVE:To assess whether amiodarone, as part of a strategy to achieve sinus rhythm, is safe and effective compared with a placebo or rate control drug in patients with persistent atrial fibrillation (AF) of more than 30 days' duration. METHODS:Randomized controlled trials comparing amiodarone with a placebo or rate...

journal_title：Mayo Clinic proceedings

authors： Doyle JF,Ho KM

更新日期：2009-03-01 00:00:00

abstract：:Treatment responses to imatinib vary among patients with chronic myeloid leukemia (CML), and definitions of treatment failure and suboptimal response have been published. This article discusses monitoring and treatment of patients with CML after failure of or suboptimal response to imatinib therapy. We reviewed articl...

journal_title：Mayo Clinic proceedings

authors： Jabbour E,Cortes JE,Kantarjian HM

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To determine the risk of congenital cardiac abnormalities associated with use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy. PATIENTS AND METHODS:We conducted a retrospective review of the medical records of all pregnant women presenting at Mayo Clinic's site in Rochester, MN, from Janu...

journal_title：Mayo Clinic proceedings

authors： Wichman CL,Moore KM,Lang TR,St Sauver JL,Heise RH Jr,Watson WJ

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To compare cardiovascular (CV) event rates and risk in patients without previous CV disease in whom atorvastatin or simvastatin was newly initiated in a managed care setting. PATIENTS AND METHODS:Patients aged 18 to 64 years in whom atorvastatin or simvastatin was newly initiated between January 1, 2003, and...

journal_title：Mayo Clinic proceedings

authors： Jacobson TA,Wertz DA,Hoy T,Kuznik A,Grochulski D,Cziraky M

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions. PARTICIPANTS AND METHODS:Thirty-three hypoadrenal women were enrolled in the study from May 1, 2002, through May 31, 2003. Twenty-eight comp...

journal_title：Mayo Clinic proceedings

authors： Dhatariya KK,Greenlund LJ,Bigelow ML,Thapa P,Oberg AL,Ford GC,Schimke JM,Nair KS

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To establish the incidence and correlation of increased left atrial volume index (LAVI) in patients with first-ever ischemic stroke. PARTICIPANTS AND METHODS:Using our institution's epidemiological database, we defined a cohort of 432 patients (cases) who underwent transthoracic echocardiography within 60 da...

journal_title：Mayo Clinic proceedings

authors： Fatema K,Bailey KR,Petty GW,Meissner I,Osranek M,Alsaileek AA,Khandheria BK,Tsang TS,Seward JB

更新日期：2008-10-01 00:00:00

abstract：:Pacemaker therapy is most commonly initiated because of symptomatic bradycardia, usually resulting from sinus node disease. Randomized multicenter trials assessing the relative benefits of different pacing modes have made possible an evidence-based approach to the treatment of bradyarrhythmias. During the past several...

journal_title：Mayo Clinic proceedings

authors： Kaszala K,Huizar JF,Ellenbogen KA

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of extended-release oxybutynin in combination with the alpha1-blocker tamsulosin in reducing lower urinary tract symptoms in men. PATIENTS AND METHODS:In this multicenter, double-blind trial performed between March 29, 2004, and June 22, 2005, 420 men aged 45 years o...

journal_title：Mayo Clinic proceedings

authors： MacDiarmid SA,Peters KM,Chen A,Armstrong RB,Orman C,Aquilina JW,Nitti VW

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To estimate the 3-month cumulative incidence of thromboembolism (TE), bleeding, and death among consecutive patients with nonvalvular atrial fibrillation (AF) who were receiving long-term anticoagulation therapy and were referred to the Thrombophilia Center at Mayo Clinic for periprocedural anticoagulation ma...

journal_title：Mayo Clinic proceedings

authors： Wysokinski WE,McBane RD,Daniels PR,Litin SC,Hodge DO,Dowling NF,Heit JA

更新日期：2008-06-01 00:00:00

abstract：:Q fever, a zoonosis caused by Coxiella burnetii, is seen throughout the world. Recent reports suggest that its incidence in the United States is increasing, with more than 30 cases reported in the US military. The disease has many acute and chronic manifestations. Endocarditis is the most common form of chronic diseas...

journal_title：Mayo Clinic proceedings

authors： Hartzell JD,Wood-Morris RN,Martinez LJ,Trotta RF

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To examine the association of medical knowledge acquisition with attendance at specific conference types during internal medicine residency. PARTICIPANTS AND METHODS:Attendance at residency core curriculum, morbidity and mortality, and medical grand rounds conferences was tracked for 195 residents who took t...

journal_title：Mayo Clinic proceedings

authors： McDonald FS,Zeger SL,Kolars JC

更新日期：2008-04-01 00:00:00

abstract：:The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed r...

journal_title：Mayo Clinic proceedings

authors： Lee JH,O'Keefe JH,Lavie CJ,Marchioli R,Harris WS

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To describe management of patients with permanent pacemaker (PPM)- and implantable cardioverter-defibrillator (ICD)-related endocarditis. PATIENTS AND METHODS:We retrospectively reviewed all cases of infection involving PPMs and ICDs among patients presenting to Mayo Clinic's site in Rochester, MN, between J...

journal_title：Mayo Clinic proceedings

authors： Sohail MR,Uslan DZ,Khan AH,Friedman PA,Hayes DL,Wilson WR,Steckelberg JM,Jenkins SM,Baddour LM

更新日期：2008-01-01 00:00:00

abstract：:The clinical impact of the association between oral contraceptive (OC) use and breast cancer risk is important given that OCs are the most commonly prescribed contraceptive agent and that more than a quarter of a million women are diagnosed as having breast cancer in the United States annually. Substantial changes to ...

journal_title：Mayo Clinic proceedings

authors： Casey PM,Cerhan JR,Pruthi S

更新日期：2008-01-01 00:00:00

abstract：:Live attenuated influenza vaccine (LAIV), commercially available since 2003, has not gained widespread acceptance among prescribers. This underuse can be traced to several misperceptions and fears regarding LAIV. This review examines both the facts (safety, immunogenicity, and effectiveness) and the most pervasive myt...

journal_title：Mayo Clinic proceedings

authors： Tosh PK,Boyce TG,Poland GA

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To review our institution's experience with patients who failed to benefit from septal artery ablation, which necessitated subsequent septal myectomy, and to examine reasons for ablation failure and outcome of myectomy after ablation. PARTICIPANTS AND METHODS:Of 550 patients who underwent septal myectomy at ...

journal_title：Mayo Clinic proceedings

authors： ElBardissi AW,Dearani JA,Nishimura RA,Ommen SR,Stulak JM,Schaff HV

更新日期：2007-12-01 00:00:00

abstract：:Primary care physicians are more likely to see patients with depression than with any other disorder except hypertension, and its management poses a challenge to busy primary care practices. The Patient Health Questionnaire-9, a simple self-administered tool of proven validity and reliability, is a commonly used scree...

journal_title：Mayo Clinic proceedings

authors： Dejesus RS,Vickers KS,Melin GJ,Williams MD

更新日期：2007-11-01 00:00:00

abstract：:To many clinicians, the assessment of health-related quality of life (HRQL) seems more art than science. This belief is due in part to the lack of formal training available to clinicians regarding HRQL measurement and interpretation. When HRQL is used systematically, it has been shown to improve patient-physician comm...

journal_title：Mayo Clinic proceedings

authors： Hahn EA,Cella D,Chassany O,Fairclough DL,Wong GY,Hays RD,Clinical Significance Consensus Meeting Group.

更新日期：2007-10-01 00:00:00

abstract：:Allergen immunotherapy involves exposing a patient to a gradually escalating dose of a specific allergen with the intention of decreasing allergic and inflammatory responses, ultimately leading to a sustained decrease in allergic symptoms. A build-up phase (once weekly injections) is followed by a maintenance phase (o...

journal_title：Mayo Clinic proceedings

authors： Rank MA,Li JT

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To evaluate whether primary care physicians document obesity as a diagnosis and formulate a management plan. PATIENTS AND METHODS:The Mayo Clinic primary care database was used to identify general medical examinations performed from November 1, 2004, to October 31, 2005, in a primary care clinic for obese pa...

journal_title：Mayo Clinic proceedings

authors： Bardia A,Holtan SG,Slezak JM,Thompson WG

更新日期：2007-08-01 00:00:00

abstract：:Breast cancer is the most common cancer among women in the United States, with an estimated 200,000 new cases diagnosed annually. A multidisciplinary focus that entails prevention, diagnosis, and treatment has led to significant strides in the reduction of breast cancer incidence and mortality. Additionally, breast ca...

journal_title：Mayo Clinic proceedings

authors： Pruthi S,Brandt KR,Degnim AC,Goetz MP,Perez EA,Reynolds CA,Schomberg PJ,Dy GK,Ingle JN

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To assess the current spectrum of causes and clinical features associated with hypersensitivity pneumonitis (HP). PATIENTS AND METHODS:We studied consecutive patients with HP diagnosed at the Mayo Clinic in Rochester, Minn, from January 1, 1997, through December 31, 2002. Diagnostic criteria for HP included ...

journal_title：Mayo Clinic proceedings

authors： Hanak V,Golbin JM,Ryu JH

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:To derive risk models for percutaneous coronary intervention (PCI) outcomes from clinical and laboratory variables available before the procedure so they can be used for preprocedure risk stratification. PATIENTS AND METHODS:Using the Mayo Clinic registry, we analyzed 9035 PCIs on 7640 unique patients from J...

journal_title：Mayo Clinic proceedings

authors： Singh M,Rihal CS,Lennon RJ,Spertus J,Rumsfeld JS,Holmes DR Jr

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To determine the sensitivity and specificity of a quantitative plasma fibrin D-dimer latex immunoassay (LIA) for the diagnosis of acute pulmonary embolism. SUBJECTS AND METHODS:Study subjects were Mayo Clinic Rochester inpatients and outpatients with suspected acute pulmonary embolism; all had undergone quan...

journal_title：Mayo Clinic proceedings

authors： Froehling DA,Daniels PR,Swensen SJ,Heit JA,Mandrekar JN,Ryu JH,Elkin PL

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:To investigate the predictors of monoclonal gammopathy of undetermined significance (MGUS) by considering not only the initial features but also the pattern of evolution of the M protein during the first years after diagnosis. PATIENTS AND METHODS:This study consisted of 359 patients diagnosed as having MGUS...

journal_title：Mayo Clinic proceedings

authors： Rosiñol L,Cibeira MT,Montoto S,Rozman M,Esteve J,Filella X,Bladé J

更新日期：2007-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) in patients with interstitial lung diseases (ILDs) is not well recognized and can occur in the absence of advanced pulmonary dysfunction or hypoxemia. To address this topic, we identified relevant studies in the English language by searching the MEDLINE database (1966 to November 2006) and ...

journal_title：Mayo Clinic proceedings

authors： Ryu JH,Krowka MJ,Pellikka PA,Swanson KL,McGoon MD

更新日期：2007-03-01 00:00:00

abstract：:For primary care physicians, obesity is one of the most challenging problems confronted in office practice. The disorder is Increasing in prevalence despite the efforts of both patients and physicians. Treatment requires a multimodality approach that addresses diet, physical activity, and behavioral issues. Medication...

journal_title：Mayo Clinic proceedings

authors： Thompson WG,Cook DA,Clark MM,Bardia A,Levine JA

更新日期：2007-01-01 00:00:00

abstract：:The metabolic syndrome is an insulin-resistant state characterized by a cluster of cardiovascular risk factors, including various combinations of abdominal obesity, glucose intolerance, hypertension, and atherogenic dyslipidemia (elevated triglyceride values, low high-density lipoprotein cholesterol levels, and small ...

journal_title：Mayo Clinic proceedings

authors： Johnson LW,Weinstock RS

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To study the impact of parental leave on extending residency training and the timing of entrance into the specialty board certification examination system. METHODS:From June 3, 2005, through December 28, 2005, primary specialty board policies regarding parental leave, absence from training, and the timing of...

journal_title：Mayo Clinic proceedings

authors： Rose SH,Burkle CM,Elliott BA,Koenig LF

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To determine the prevalence of restless legs syndrome (RLS) in native South Americans and identify the impact of geographic location. PARTICIPANTS AND METHODS:An epidemiological telephone survey of RLS symptoms involving natives from coastal and mountainous areas was performed during July 2, 2004, through Se...

journal_title：Mayo Clinic proceedings

authors： Castillo PR,Kaplan J,Lin SC,Fredrickson PA,Mahowald MW

更新日期：2006-10-01 00:00:00

abstract：:Hypoxic liver injury is defined as a massive, but transient, increase in serum transaminase levels due to an imbalance between hepatic oxygen supply and demand in the absence of other acute causes of liver damage. It typically occurs in elderly individuals with right-sided congestive heart failure and low cardiac outp...

journal_title：Mayo Clinic proceedings

authors： Ebert EC

更新日期：2006-09-01 00:00:00

abstract：:Giant cell arteritis and polymyalgia rheumatica were described separately more than 100 years ago. However, the original reports of both conditions were neglected for many years. After the article by Horton et al on giant cell arteritis in the 1930s and studies published by others in the 1940s, giant cell arteritis be...

journal_title：Mayo Clinic proceedings

authors： Hunder GG

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To examine the use of tests that measure ejection fraction (EF) and the use of coronary angiography among patients with an initial diagnosis of heart failure (HF). PATIENTS AND METHODS:All potential cases of incident HF in Olmsted County, Minnesota, between 1979 and 1999 were identifled. In a random sample o...

journal_title：Mayo Clinic proceedings

authors： Kurtz CE,Gerber Y,Weston SA,Redfield MM,Jacobsen SJ,Roger VL

更新日期：2006-07-01 00:00:00

abstract：:People with hypertension have a high prevalence of insulin resistance and are at relatively high risk of developing type 2 diabetes mellitus. It is becoming increasingly evident that antihypertensive agents have disparate metabolic effects. For example, recent clinical trials indicate that agents that interrupt the re...

journal_title：Mayo Clinic proceedings

authors： Stump CS,Hamilton MT,Sowers JR

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:To analyze the effect of adjuvant perfusion techniques of the distal aorta on the outcome of traumatic thoracic aortic transections. PATIENTS AND METHODS:From 1973 to 2004, 72 patients (mean age, 39 years) with thoracic aortic transections arrived alive at the emergency department. Nineteen patients arrived ...

journal_title：Mayo Clinic proceedings

authors： Crestanello JA,Zehr KJ,Mullany CJ,Orszulak TA,Dearani JA,Puga FJ,Sundt TM 3rd,McGregor CG,Daly RC,Schaff HV

更新日期：2006-05-01 00:00:00

abstract：:Three case reports in this article illustrate the diagnostic methods used and the treatment course encountered for many patients with diabetic peripheral neuropathic pain (DPNP). Each case addresses an aspect of DPNP: pain that appears to be refractory to initial therapy, DPNP occurring with other medical conditions, ...

journal_title：Mayo Clinic proceedings

authors： Belgrade MJ,Cole BE,McCarberg BH,McLean MJ

更新日期：2006-04-01 00:00:00

abstract：:Skin cancer has become the most common neoplasm in the United States. With early diagnosis and appropriate management, most skin cancers have an overall 5-year survival rate of 95%. Cutaneous malignant melanoma (CMM), however, has a significantly higher morbidity and mortality, resulting in 65% of all skin cancer deat...

journal_title：Mayo Clinic proceedings

authors： Cummins DL,Cummins JM,Pantle H,Silverman MA,Leonard AL,Chanmugam A

更新日期：2006-04-01 00:00:00

abstract：:During the past decade, major advances have been made in vitamin D research that transcend the simple concept that vitamin D is Important for the prevention of rickets in children and has little physiologic relevance for adults. Inadequate vitamin D, in addition to causing rickets, prevents children from attaining the...

journal_title：Mayo Clinic proceedings

authors： Holick MF

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To describe clinical, radiological, and histopathologic features of diffuse bronchiolar disease due to chronic occult aspiration. PATIENTS AND METHODS:We identified 4 patients encountered from July 2001 to January 2004 who had persistent respiratory symptoms and lung Infiltrates and who were eventually diagn...

journal_title：Mayo Clinic proceedings

authors： Barnes TW,Vassallo R,Tazelaar HD,Hartman TE,Ryu JH

更新日期：2006-02-01 00:00:00

abstract：:Atherosclerosis is a diffuse, systemic disease that affects the coronary, cerebral, and peripheral arterial trees. Disruption of atherosclerotic plaques leads to thrombus formation and arterial occlusion. This unpredictable and potentially life-threatening atherothrombotic sequence underlies clinical events such as an...

journal_title：Mayo Clinic proceedings

authors： Vorchheimer DA,Becker R

更新日期：2006-01-01 00:00:00